Science
Science
Alkaloids, pharmacology, research.
Kratom can injure the liver. The case reports cannot tell you how often
Case reports and a US liver-injury registry show that kratom has caused liver injury in some people. No study we found measures how often it happens, or who is at risk.
Kratom in mortality data: "involved" versus "caused", and what the coroner reports show
US overdose data counted 1,221 deaths involving mitragynine in the year to December 2025. "Involved" means the word appeared on the death certificate. That is not the same as caused.
Kratom and driving: one state convicts on a detectable trace, and the evidence is ten drivers
Wisconsin has a zero-tolerance drugged-driving offence reaching mitragynine. England and Wales can only prosecute impairment. The research on whether kratom impairs driving is one pilot study.
Kratom's alkaloids: what mitragynine and 7-hydroxymitragynine are, and what they do
Kratom contains more than forty alkaloids, led by mitragynine and the more potent 7-hydroxymitragynine. What they are, how they act on the brain's receptors, and how much is really known in humans.
Kratom withdrawal: what the evidence shows, and how thin it still is
Regular kratom use can produce an opioid-like withdrawal syndrome, reported across surveys, animal studies and case reports. But there are no controlled human trials, and the evidence stays thin.